The Definitive Guide to ceesdekker
The Definitive Guide to ceesdekker
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Rotary movement of DNA rotors on nanopores. Best row: Uncooked movie of the Cy5 channel of each and every rotor. Middle row: corresponding solitary-particle localization outcomes of both of those finishes of the DNA rotors. The situation of the current body is marked as orange and blue dots, and also the trajectory of The ten frames prior to The existing frame is demonstrated as strong traces.
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Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I
Given that 2000, Dekker has shifted the most crucial concentrate of his get the job done towards biophysics in which he scientific tests the properties of single biomolecules and cells using the instruments of nanotechnology. This change of area was driven by his fascination for that extraordinary functioning of biological molecular constructions, and also via the long-phrase point of view that numerous interesting discoveries may be anticipated On this subject.[five] Latest strains of research in his biophysics team are in the areas of:[6]
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The coiled-coil on the human Rad50 DNA restore protein incorporates distinct segments of elevated versatility
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with analysis from DNA supercoiling research of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on finding out cell division with microbes on chip, when his final interest is from the route of recognizing artificial cells.
2000, discovery that nanotubes can have remarkable substantial current densities; settled the controversial difficulty of electronic transport by DNA molecules by measurements of insulating behavior at the single molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
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At this time, we also understood that it ought to be doable to employ only one semiconducting carbon nanotube to help make a transistor — and we established out to make it. We stretched personal semiconducting nanotubes across metallic electrodes and used the fundamental silicon substrate for a gate electrode, developing The fundamental three-terminal structure of the discipline-impact transistor (Fig.
Because 2000 ceesdekker.net he moved to one-molecule biophysics and nanobiology, with analysis from studies of DNA loop extrusion and supercoiling to DNA translocation by nanopores. A lot more recently his investigation has focused on finding out chromatin structure and mobile division with bacteria on chip, when he can also be seeking to in the end Establish synthetic cells from The underside up.
Cees Dekker is Distinguished College Professor at TU Delft. Qualified being a physicist, he pioneered nanotechnology with a lot of discoveries on carbon nanotubes from the nineties. Due to the fact 2000, he moved to solitary-molecule biophysics and nanobiology. His recent analysis focuses on (i) nanopores for protein sequencing; (ii) chromosome framework, specifically SMC motor protein; and (iii) creating a residing synthetic cell from lifeless molecules. Dekker is definitely an elected member of the KNAW and fellow to the APS as well as IOP.
2008, first observation of protein-coated DNA translocation through nanopores; resolved the origin of the electrophoretic drive on DNA in nanopores; learned a big velocity raise of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes